ABSTRACT
Rheumatoid arthritis (RA) is a systemic disease characterized by chronic inflammation of synovial joints accompanied by a marked acute phase response, and interleukin-6 (IL-6) is a major mediator of the inflammatory response which is involved in the induction of acute phase protein, To evaluate the significance of IL-6 levels in patients with RA, IL-6 activity was measured by radioimmunoassay in 13 patients with RA and 5 patients with traumatic arthritis (TA) or osteoarthritis (OA) was used as a control group. Serum IL-6 activity was significantly elevated in 2 RA patients without treatment compared with that of 11 RA patients with treatment and all the TA and OA patients. Synovial fluid IL-6 activity was elevated in all RA patients (markedly elevated in 2 RA patients without treatment) compared with that of TA and OA patients. Immunohistochemical analysis of synovial tissue from 3 RA patients revealed strong expression of IL-6 in most inflammatory synovial cells. The results indicate that IL-6 level, especially that of synovial fluid, is related to disease activity in patients with RA.
Subject(s)
Humans , Acute-Phase Proteins , Arthritis , Arthritis, Rheumatoid , Inflammation , Interleukin-6 , Joints , Osteoarthritis , Radioimmunoassay , Synovial FluidABSTRACT
The ultrasound is also helpful to make the diagnosis of a variety of soft tissue tumors bacause of its safety, low cost, non-invasiveness and usefulness. We analysed ultrasonographic findings of 43 cases of soft tissue tumors which were histopathologically confirmed by biopsy and obtained the following results. The ultrasonography could effectively image not only the presence, size and location of the lesion, but also the relationship between the lesion and the adjacent structures. And this method could easily identify the consistency of the lesion, solid or cystic nature, be used to guide the percutaneous biopsy and aspiration without exposure to radiation, and afford the differentiation of malignant lesion from benign one. It could also define the eritities of soft tissue tumors by the nature of internal echo, margin of the lesion, internal echo homogeniety, post-acoustic enhancement, and so on.